A few of my colleagues, Julie Kowalski and Chris English, have written blogs about the original CD based Pro ezGC modeling software (ezGC really IS cool! and Pro ezGC Software: Manna from Heaven or a Clunky DOS-Based Program). The basics of this software is to add a library of compounds by entering the retention times of a slow analysis and a fast analysis, add column and instrument conditions and then it will model separations for you. I have used this tool many times, and sometimes I don’t like having to enter in all of that information, but it does reduce method development time if you have a tricky isobaric interference. The software is admittedly a little clunky and has some bugs to it, but once you know the work around it can be a very powerful tool.
Well lucky for you we have taken the basics of the original Pro ezGC software and made this powerful tool even easier by updating the user interface, adding a huge library of compounds so you don’t have to, and made it available for FREE on the website (link). We currently have thousands of the most common compounds on a variety of column phases, and we will be adding more as time goes on, based on feedback from customers. Now, all that you need to do is enter in a list of compounds that you would like to be separated and voila! The EZGC Chromatogram Modeler will then give you a modeled chromatogram separating all (hopefully) of your compounds of interest. If you think that the results are strange or would like to change some of the values (oven temperatures, maybe column choice or dimensions) just contact the Restek Technical Service using a very handy link in the big yellow box and they can help you out with more specifics.
Hopefully this simplified approach to the EZGC software will help with some initial method development. It has saved me a lot of time in the lab, and now that you don’t have to worry about outdated software and inputting libraries, it should save you even more time! Let us know what you think, and if there are analytes missing from the library let us know, and maybe we can add them to the library in the future.