Posts Tagged ‘large volume injection’

Solvent Focusing – The Key to Successfully Implementing CSR-LVSI

It’s been over a month since my last post on Concurrent Solvent Recondensation – Large Volume Splitless Injection (CSR_LVSI), so I thought I would cover solvent focusing, a key element of the technique, today. The CSR-LVSI solvent peak widths are minutes larger than those seen in a typical 1 µL injection. Figure 1 shows the difference in solvent […]

Sometimes Peak Defects Are Not the Sign of a Problem

Last month, I demonstrated the feasibility of a 250 µL injection in a split/splitless injection port, using the EPA Method 521 (nitrosamines in drinking water) list. As you can see in the chromatogram below, seven of the eight peaks are nice and symetric. Peak number 2, however, shows exaggerated fronting. N-nitrosomethylethylamine is the only compound on […]

Is there a limit to the volume you can inject into an agilent split/splitless inlet?

Theoretically, the answer is no; the limiting factor of a concurrent solvent recondensation – large volume splitless injection (CSR_LVSI) is the surface area available to support a stable film of recondensed solvent. If you read my previous post, which utilized a 50 µL injection to meet lower detection limits for 1,4-dioxane and various nitrosamines, you may […]

Visit My E-Poster at PittCon 2013 Today (Thursday, March 21st) to See an Animation of the CSR-LVSI Mechanism

  I’ll be at my posters between 10 and 12 tomorrow morning, so swing on by if you have any CSR-LVSI questions or want to check out the animation. Room 204ABC, abstract numbers 2500-4P (EPA 522; 1,4-dioxane in drinking water) and 2500-5P (semivolatiles in drinking water). I’ve included a preview. Also, Jaap is presenting his paper, Bonded […]