Posts Tagged ‘Standards’

What can I use to Qualify my HPLC instrumentation?

If you are setting up LC instrumentation in a new lab, you may find yourself looking for ways to perform Operational Qualification (OQ) tests. The requirements for qualifying a new instrument vary, depending on regulatory needs and SOP requirements, as well as the specific instrumentation. They might involve tests to confirm parameters such as solvent […]

Finding Reference Standards Just Got a Lot Easier

The range of reference standards available from Restek is very wide, which is great. But finding a particular formulation among all those options can be a challenge. And, let’s face it, filling out a form to inquire about a custom mix can be a pain in the neck. That’s why we built our new Reference […]

You want them, I got them…a lot of them: pesticides GC-MS/MS transitions

I can tell you that determining transitions (SRMs) for GC-MS/MS can be quite challenging with so many precursor ions to evaluate. I spent a considerable amount of time optimizing transitions for our GC Multiresidue Pesticide Kit which has 203 compounds. That is a lot of transitions to evaluate! I also tested my chromatographic method for […]

Troubleshooting standard response issues

Is the problem with standards or only with samples? If the low response is only with extracted samples, the problem is elsewhere in your method. Please see the blog post Now you see it, now you don’t-Troubleshooting method recovery problems. When was the standard ampule opened? If not fresh, open a new one. As mentioned […]

Extending the expiration date on a reference standard

Restek occasionally receives requests from customers on extending the expiration date on their certified reference material or standards that we manufacture. The short answer to this question is no, Restek conducts real-time stability studies and accelerated stress tests to establish reliable expiration dates. Use beyond the identified expiration date is neither recommended nor guaranteed. While […]