Archive for the ‘Detection Techniques’ Category

A better way to configure your EZ No-Vent GC-MS Connector Part II

Last time, I wrote a blog (here) that showed a better way to configure the EZ No-Vent in the software so that the column length didn’t need to be manipulated. I kept the volumetric flow the same, and showed different ways to minimize the negative chromatographic effects of the reduced linear velocity. Today, I’m going […]

A better way to configure your EZ No-Vent GC-MS Connector

If you are using the EZ No-Vent for Agilent mass spectrometers (cat.# 21323), you are probably tricking your instrument into working properly by inflating the length of your column in your acquisition software. If you have MassHunter, or a recent version of MSD ChemStation  (G1701EA), you don’t have to do this. Instead of configuring your […]

General (very general) guidelines to help meet GC detection limits.

Sometimes we (tech service) receive requests from customers who cannot meet detection limits when developing a new method or when trying to follow a current method. They ask for advice on how to meet these limits.  As a result, I decided to provide some (very) general guidelines that I would follow back-in-the-day when I would […]

Cassini-Huygens: 20-Year Mission Accomplished

On October 15th, 1997, the $3 billion spacecraft went on a seven year, two-billion-mile journey to study the planet Saturn along with its moons and rings. After arriving at the Saturnian system, Cassini deployed the 700-pound Huygens probe to its largest moon, Titan. At 100 miles above the surface the aerosol collector pyrolizer (ACP) and […]

Cannabis Residual Solvents Using MS Detection – I’m Not Hungry but I’ll Eat My Words Anyway

After coming back from a huge lunch at the Bellefonte Wok, a favorite Restek lunch spot, I’m completely stuffed, but I have to eat my words from a previous blog. In this blog, I made the case against using MS detection for headspace analysis of residual solvents in cannabis concentrates due to interference between the […]

GC-API-MS for BDEs with N2 at BFR2016

OK Jack, enough of the acronyms; this isn’t a word puzzle… Recently I let ChromaBLOGraphy readers know of our work on using gas chromatography (GC) with atmospheric pressure ionization (API) – mass spectrometry (MS) for analysis of brominated diphenyl ethers (BDEs) employing nitrogen (N2) carrier gas, which was presented at BFR2016 (BFR standing for Brominated […]

Fast gas chromatographic residue analysis in animal feed using split injection and atmospheric pressure chemical ionization tandem mass spectrometry

In a recent ChromaBLOGraphy post I mentioned that we are doing a campaign on “shoot-and-dilute GC”, also known as split injection GC, at RAFA 2015. A paper just published by Tienstra, Portolés, Hernández, and Mol used split injection with APGC for pesticide and other residue analysis in animal feed to achieve many of the benefits we’ve been […]

High Source Temperatures and Meeting EPA Tuning Criteria

My first blog here at Restek was a demonstration of how increasing the source temperature could improve the raw response of 2,4-dinitrophenol while maintaining the relative response. Four years later I’m here with the promised follow-up on the elevated source temperature effects on tune evaluations (and making adjustments via target tuning). This blog is going to deal […]

Which Source Configuration is Right for your Application?

If you have an Agilent 5973, 5975, or 5977 mass spec, there is a simple change to the configuration you can make to optimize its performance. By default, these systems come with a 3 mm drawout plate (or extraction lens) in their source assemblies. According to the manufacturer, this 3 mm lens is ideally suited for […]

Philae: Goodnight but Not Goodbye. Unlocking the Origins of Life: Comet 67P/Churyumov-Gerasimenko

On September 28th, 1969 a bright fireball exploded, shaking houses as it lit up the daytime sky outside of Murchison, Australia. Over the next forty-five years scientists have studied the Murchison Meteorite and found 14,000 compounds to include 92 different amino acids. Of the amino acids discovered, only 19 are found on earth. This rock, […]