Electronic Cigarettes Part III: We’re gonna vape on the EZGC bandwagon.

band-wagon

The title says it all… we’re taking our e-cig method and jumping on the EZGC Method Translator and Flow Calculator bandwagon. Why… well because all the cool kids are doing it. No seriously… to simply reiterate how easy it is to use the Method Translator. In fact, the EZGC Method Translator makes life so easy you can kick back, put your feet up, and vape away on an e-cig. Okay, so maybe we do not endorse such behavior, but you get the point!

So we (Amanda, Colton, and me) took our e-cig solution analysis method and used the method translator to switch from helium to hydrogen carrier gas. It was as simple as plugging in our current method parameters (which you may find in part II of this blog series) and then letting the translator do the work. As you will see below, the flow bumped up to 2.5 mL/min and the oven ramping jumped to 54 °C/min. All of this correlates to our 4.84 min run dropping down to a mere 3.11 min. But most important… we no longer use helium!

EZGC

 

Now let’s take a look at how this… well… looks!

E-Cigs Part III C-Gram I

Pretty nice, but let’s compare this to our previous method. The following overlay will show you the difference between the “old” helium (blue trace) and “new” hydrogen (red trace) carrier gas methods:

E-Cigs Part III C-Gram II

 

Now let’s look at this from a different angle. Here the overlay has taken into account the off-set due to hydrogen being faster:

E-Cigs Part III C-Gram IIB

Once again, looking good! Now I know some of you may be saying… “what the heck is this guy thinking; I can’t ramp at 54 °C/min… expletive!!!”… Which is certainly a fair statement, minus the expletive. We just want to demonstrate what you may achieve with a fast-ramping oven like we have. So for the rest of you… our original 35 °C/min ramping method should work well. So let’s just capitalize on the hydrogen like so:

E-Cigs Part III C-Gram III

Even with the slower oven rate, the hydrogen method gets our compounds eluted a minute faster. The problem is that we left an extra minute hanging out there in no-mans-land. So we can recoup that minute by simply dropping the final oven temperature from 260 to 240 °C like so:

E-Cigs Part III C-Gram IV

So there you have it… several hydrogen-based methods for the analysis of electronic cigarette solution. Regardless of which method you chose… the EZGC Method Translator and Flow Calculator made for a simple transition between helium and hydrogen carrier gas. I literally ran all 4 chromatograms (yes, I know there are technically 5, but there was a duplicate in there) back-to-back as you see above… with no “trial and error” or “guess and check”. Now we have a shorter run, with super crisp peaks, and no helium consumption. The problem is… I now have to figure out what to do with all this extra time!?!?

 

 

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