Fast gas chromatographic residue analysis in animal feed using split injection and atmospheric pressure chemical ionization tandem mass spectrometry

In a recent ChromaBLOGraphy post I mentioned that we are doing a campaign on “shoot-and-dilute GC”, also known as split injection GC, at RAFA 2015. A paper just published by Tienstra, Portolés, Hernández, and Mol used split injection with APGC for pesticide and other residue analysis in animal feed to achieve many of the benefits we’ve been extolling for split injection with sensitive detectors.  Highlights from their paper were listed as:

Fast GC run time: < 10 min.  (JC note: fast cycle time too because of higher initial oven start temp)

Less matrix on the GC column and in the MS source.  (JC note: increased uptime)

Better compatibility with acetonitrile extracts (QuEChERS).  (JC note: most of solvent is split off before GC column)

Applicable to complex feed matrices.  (JC note: APGC with MS/MS is very sensitive and selective)

APGC Split Figure

One Response to “Fast gas chromatographic residue analysis in animal feed using split injection and atmospheric pressure chemical ionization tandem mass spectrometry”

  1. They could do this with N2 and 20/0.15 like we did with waters APCI..

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