Posts Tagged ‘LC-MS/MS’

Dilute, Shoot, and Elute – am I missing anything? YES!

  Everyone’s lab is different in terms of how many samples per day are processed, but they all share the common pain point of sample preparation. Some samples like blood and plasma need a significant amount of prep to remove proteins, phospholipids, and salts, whereas labs running urine or drinking water samples can “get by” […]

EXP Fittings: Which Nut Do I Need?

Our brilliant friends at Optimize Technologies are continually innovating and making our lab lives easier. We love their patented EXP Titanium Hybrid Ferrule technology that is truly universal. You can use it on any tubing, any 10-32-port, any instrument—wrench-tight to 20,000 psi. This fully UHPLC-capable EXP ferrule is used with all EXP nuts. Restek offers […]

Pesticide analysis for cannabis flower: method and data overview

Pesticides in cannabis has been a hot topic lately and we have been getting many requests for help with this analysis. We did work on pesticide residue testing in cannabis about 6 years ago. At that time, we were limited to testing our methods with a small amount of seized material. Recently, we have been […]

Here’s to HILIC: tailor-made for the MS analysis of polar analytes and highly water-soluble species

There is much discussion these days about Hydrophilic Interaction Chromatography (HILIC) and the options it provides today’s analysts. And there should be.  It’s powerful for analysts working with polar metabolites or highly water-soluble compounds, namely when using MS/MS techniques. Since phase chemistry is Restek’s specialty, and we have designed our Raptor SPP LC column line for […]

Raptor Biphenyl LC Columns provide the data needed for global antibiotic testing

Because the widespread use of preventative veterinary antibiotics has resulted in increased antimicrobial resistance in humans, the US Food and Drug Administration (FDA) released guidelines to address the issue in food animals (December 11, 2013). Similar constraints are also prevalent in the European Union.  Recently, European Researchers1 developed a validated method for the determination of […]

A C18 is a C18, right?

    Sorry, that actually is not true. Although many methods only list the USP code L1 for all C18 HPLC columns, there are many different varieties of C18 columns available from Restek. Here are some of the ways they may differ:   Differences in Silica Depending on the silica particle that the C18 phase […]