Author Archive

Chiral Separation on a C18 Column? Separation of d- and l- Amphetamines Part IV

I am back here to complete my Amphetamines blog series. In my previous posts, I have discussed the importance of separating the chiral d- and -l isomers to accurately identify the illicit isomer using an achiral method on a Raptor C18 column employing a pre-column derivatization technique, sample prep strategies and derivatization efficiency in my […]

Chiral Separation on a C18 Column? Separation of d- and l- Amphetamines Part III

To continue my blog parts 1 & 2 (Part 1:https://blog.restek.com/ p=67087,https://blog.restek.com/chiral-separation-on-a-c18-column-separation-of-d-and-l-amphetamines-part-ii/) , where I have discussed the importance of separating the chiral d- and -l isomers to accurately identify the illicit isomer using an achiral method on a Raptor C18 column employing a pre-column derivatization technique. Today I’d like to discuss more about the sample […]

Chiral separation on a C18 column? Separation of d- and l-amphetamines, Part II

To continue my blog part 1 (Part 1:https://blog.restek.com/?p=67087) , where I have briefly discussed the importance of separating the d and l isomers to accurately identify the illicit isomer using an achiral method on a Raptor C18 column employing a pre-column derivatization technique. Today I’d like to discuss more about the matrix of interest, sample […]

Chiral separation on a C18 column? Separation of d- and l- Amphetamines, Part I

Did you know that chiral chemistry was discovered by Louis Pasteur, a French chemist and biologist in 1848? However, it took about a century to find that chirality plays a key role not only in the life of plants and animals, but also in several aspects of drug design, and both pharmaceutical and illicit drug […]