Archive for the ‘Cannabis’ Category

Modifying QuEChERS for complicated matrices- Dry Samples

Before getting in to this discussion, I recommend reading my previous blog post first regarding classical applications for methods based on Quechers. https://blog.restek.com/quechers-dspe-selection-which-one-is-best/ QuEChERS methods were originally written to analyze pesticides in fruit and vegetable matrices, most of which have high water content and low fat content. More recently, the technique has been used for […]

Terpene Analysis Approaches – Part IV

We are back at it with another blog about terpene analysis! If you did not catch my previous post, be sure check it out here before moving on. Last time, I finished up by discussing how we would move away from analyzing terpenes in standards and dive into in-matrix analysis. Well…I lied. I’m sorry, but […]

Tips on the analysis of pesticides and mycotoxins in cannabis products: Matrix matters! (Part II)

In part I of this blog series, we learned about matrix effects, how to assess them, and how to address them (you can check the blog here). One of the main conclusions of part I was the importance of using matrix matched calibration as the means to account for possible ionization effects in LC-MS/MS, and […]

Time to make lemonade with your Agilent 1100 – HPLC routine maintenance

They say when life hands you lemons, make lemonade. In this case, the COVID-19 pandemic has handed us all more downtime, so let’s talk about one aspect of a testing lab that tends to get overlooked or given less priority than other daily tasks: routine maintenance. The combination of downtime cannabis labs are experiencing due […]

Quechers dSPE selection- which one is best?

Method development for Quechers sample cleanup can be a complicated task. Not only does the analyst need to make sure their analytes of interest can be recovered, but the matrix interferences must be removed enough to make the quantitation possible and reliable. It makes sense that selecting the best dSPE products is highly dependent on […]

Tips on the analysis of pesticides and mycotoxins in cannabis products: Matrix matters! (Part I)

The growing variety of cannabis products that are currently available in the market speaks volumes about the creativity of entrepreneurs within the industry. Vapes, lotions, balms, cookies, hard candy, gummies, infused drinks, chocolate, fudge, soaps, and tinctures are only a handful of the product types that are currently being commercialized in this ever-growing market. Such […]

Terpene Analysis Approaches – Part III

It’s time to dive back into analyzing terpenes! Previously, we looked at two types of sample preparation for analyzing terpenes via HS-Syringe and HS-SPME. If you missed those blogs, be sure to check them out here and here before moving on! In my last blog, I showed that HS-SPME outperformed the HS-Syringe when analyzing terpenes. […]

The eVol – Investigating a Liquid Handling Tool to Improve Consistency and Reliability for Calibrations

We’re taking you to Austin, Texas to meet the amazing team at Santé Laboratories for this investigation! This project, led by the analytical team at Sante Laboratories, put the eVol in use and compared it to standard pipetting techniques in the generation of analytical calibration curves. Wait….what? You might be thinking to yourself….What’s an eVol? […]

LC Preventative Maintenance Tips and Tricks – The UltraShield

We’re providing a creative trick for extending guard cartridges and column lifetimes.  This preventative maintenance consumable also acts as a handy troubleshooting tool for problematic back pressure readings.  Drum roll….The UltraShield! https://www.restek.com/pdfs/730-70-003.pdf Normally, the UltraShield is used as an affordable UHPLC pre-column filter and takes the place of a guard column.  These filters have minimal […]

Terpene Analysis Approaches – Part II

Welcome back my fragrance fanatics! Today, we continue exploring approaches for analyzing terpenes. If you missed part one, you can get caught up here! Last time, we discussed two HS approaches that just flat out stunk! So, it’s time to make some adjusts. The first thing to check was the way our samples were prepared. […]