Archive for the ‘LC’ Category

Glyphosate and… Cannabis?

By now, you’ve likely heard of Roundup. Roundup is the trade name for the broad spectrum herbicide developed by Monsanto in 1974 and it’s one of the world’s most widely used agricultural weed killers. Roundup and other herbicides like it contain a polar organophosphorus compound called glyphosate. Glyphosate is degraded predominantly by bacteria into aminomethylphosaphonic […]

Cannabis Potency Testing & Calibration Curves

Calibration curves are an essential part to potency testing. A question often brought up by customers is “how many calibration points are needed for a calibration curve?” The answer to this question isn’t the same for everyone, as it depends on your laboratory’s objectives and accreditation body guidelines. Since the answer could potentially be different […]

Analyzing THC Concentrates? Look for Isomers!

As we learn more about the chemical constituents of cannabis, more cannabinoids are being discovered and with it more THC isomers. You are probably very familiar with the two most commonly tested: Delta-9-THC and Delta-8-THC https://www.restek.com/Technical-Resources/Technical-Library/Video-Library/Did-You-Know-THC-Has-Isomers. There have been a total of 30 different isomeric forms of THC discovered thus far including different conformations. These […]

Is my LC instrument generating high pressure by itself?

We have had several blog posts and articles that discuss high backpressure observed in LC systems. Much of this discussion involves how to determine if the problem is in the column and what to do about it. Here are links to several of these: The Clog Blog Building up pressure on HPLC? Technical Service Red […]

CBD Infused Beverages: The Recovery Dilemma

The Farm Bill of 2018 has opened a lot of doors in the cannabis industry. The effects are prominent in selection of cannabinoid containing products offered on the market. One such product that is gaining popularity in the industry are CBD infused drinks. These beverages present a unique challenge compared to other matrices because of […]

Troubleshooting 101

Like most folks who work in the lab, you likely have had some downtime in the lab due to various reasons, like a column, instrument, sample prep, standards, and even application or method conditions. Troubleshooting then commences. Details are often needed, in order to get the bigger picture. One of the most important troubleshooting tools […]

Using EZLC to adapt an LC pesticide method for lower pressure

  Our most popular and successful LC column for the broadest range of pesticides is the Raptor ARC-18 column. We are able to retain, provide good separation and peak shape even for many of the more polar pesticides. Whether your matrix is a food, agriculture crop or a cannabis product, the Raptor ARC-18 will probably […]

Potency: Useful Techniques

The most labor-intensive part of determining the potency of samples containing cannabinoids is extraction. Due to a plethora of matrices, from candy, baked goods, lotions, and so on, selecting the most suitable extraction method can also be a challenge.  The following video and technical article will guide you through that initial process: How Potent is […]

Getting Your LC Up and Running Again

Welcome Back!  You and your lab have been through a lot these last few months and now it’s time to get your LC back up and running.  After it has been down for a few months, it likely needs a little TLC before it’s performing optimally again.  Just like a car that sits around for […]

Modifying QuEChERS for complicated matrices- High Fat Samples

This post is part of a series on QuEChERS. Here are links to the previous two posts, in case you may wish to catch up before reading this one: QuEChERS dSPE selection-which one is best? Modifying QuECHERS for complicated matrices- Dry Samples (See Jana’s post here for further details on dry samples: QuECHERS approach optimization […]